Injectable Salmon DNA: A Trend Worth Questioning

I won't lie to you, I wrote this blog a while back and hesitating sharing this due to the controvery in the aesthetic community around this treatment. Now that more information has come to light, let's get into it! While the buzz around this trend was growing, and we've recently discovered it is not approved for injecting... (insert spooky music here). I want to take a moment to address the facts, the research, and why, at Noir Medical Aesthetics, we never jump on trends at the expense of patient safety.

What is Injectable Salmon DNA?

Injectable Polydeoxyribonucleotide (PDRN) treatments, derived from salmon DNA, are said to promote skin healing, boost collagen production, and improve skin elasticity. While this sounds promising, it's important to note that current studies primarily focus on its use in topical applications rather than injectables. In fact, this product is originally intended for topical use, making its injectable application an off-label and unverified approach. While this may be a great topical option, such as for post-microneedling or post-procedure care, it again, is not FDA-approved for injectables.

Lack of Clinical Data for Injectables

Despite its popularity, there is a significant lack of clinical studies supporting the safety and efficacy of injectable salmon DNA treatments. As a medical aesthetics practice that prioritizes patient well-being, we believe in waiting for products to be thoroughly vetted through independent clinical trials before even considering offering them. (Again we're referring to injectable useage)

NP Neeki, our founder and injector, follows a strict protocol when evaluating new treatments. She waits at least 1-2 years after a product hits the market to assess real-world results, studies the fine print, and analyze clinical research before determining its safety and efficacy. Just because something is trending does not mean it is safe or suitable for everyone.

Lessons from Past Trends: The Hyaluron Pen Fiasco

History has shown us the dangers of blindly following trends. Take the hyaluron pen, for example. Marketed as a needle-free way to inject filler, it quickly became popular—until the risks became apparent. The lack of precision, the absence of medical oversight, and the inability to control product placement led to complications, including lumps, infections, and vascular occlusions. This so-called "treatment" is not FDA-approved, and the substances being pressurized into the skin are often of questionable origin.

Similarly, just because injectable salmon DNA is trending does not mean it should be injected into your skin without thorough research and medical oversight. PDRN useage should remain for its intended topical use.

Do Your Research & Ask Questions

At Noir Medical Aesthetics, we cannot stress enough how important it is for patients to do their own research when considering a new treatment. Just because your friend claims a product gave them "glowing skin" does not mean it is safe, effective, or appropriate for you.

Always ask:

• Is there solid, peer-reviewed research supporting its use?

• Is it FDA-approved for the intended purpose?

• What are the potential risks and side effects?

• Is the treatment being performed by a qualified medical professional?

  
  

While injecting PDRN is a big no-no, we love using it topically during microneedling — which is exactly what it’s intended for! When paired with microneedling, PDRN has shown amazing results in boosting skin repair and rejuvenation. It helps enhance hydration, improve texture, and promote a radiant, healthy glow. This makes it the perfect choice for anyone looking to elevate their microneedling treatment without the need for blood draw or PRF — giving your skin that luminous, dewy finish we all love.

Your safety is our top priority, and we encourage all of our patients to approach trending treatments with a critical eye. If and when injectable salmon DNA treatments prove to be safe and effective, we will be the first to review them with a scientific and ethical approach. Until then, we will continue to stand by our philosophy of prioritizing evidence-based medicine over fleeting trends.

Have questions about aesthetic treatments? Schedule a consultation with us—we’re always happy to help guide you toward safe, effective, and scientifically-backed options for your skin and beauty goals. For more information visit: ( NIH , FDA, YT Vid On PDRN)